Ever wondered why major injuries are sometimes pain-free? Ever wondered how you got that bruise on your leg? Ever wondered why your legs hurt more one day on the bike than the other? Why 1 in 5 people have chronic pain but only some of them have evidence of chronic injury? Ever wondered why sadomasochists do what they do when it hurts so much? Ever wondered whether it really hurts at all? These questions entertain pain scientists, who come in all shapes and sizes, from epidemiologists to molecular biologists, but they share one perspective—that pain is subserved by very complex biological events. In this talk, Professor Moseley presents evidence, from anecdote to error bars, that pain is not a marker of tissue damage or pathology. He argues that such a conceptualisation of pain, although popular, is based on an outdated model, is unhelpful when it comes to taking on the burden of chronic pain, and would be a daft situation anyway, destined to drop us out of the gene pool quick smart. Professor Moseley outlines some of the major advances in the clinical management and prevention of chronic pain, as he sees them, from the perspective of a clinical scientist working in interdisciplinary research and clinical teams.